expression of chemokine receptors on th1/th2 cd4+ lymphocytes in patients with multiple sclerosis

نویسندگان

alireza andalib

immunology department hassan doulabi

immunology department mohammadreza najafi

neurology department, isfahan medical school mehdi tazhibi

biostatic department, isfahan university of medicalsciences, isfahan, iran

چکیده

background: th1 cells preferentially express cxcr3, ccr5 and ccr6, while ccr3 and ccr4 are predominantly expressed by th2 cell subsets. multiple sclerosis (ms) is a th1 cell-dependant chronic inflammatory disease of the central nervous system, and immunomudolatory cytokines could alter the chemokine expression pattern of these lymphocyte subsets. objective: this study was performed to measure chemokine receptor expression on cd4 t cells for evaluation of th1/th2 dominantly in ifn-β treated patients. methods: flowcytometry was used to detect chemokine receptor expression on cd4 t cell population in pbmcs obtained from ms and healthy control groups. twenty six ms patients participated in this study before and after ifn-β therapy and the same number of healthy individuals were included. results: the percentage of lymphocytes was 41.28% ± 10.30 in the blood of ms group compared with 36.88% ± 5.51% in the control group (p=0.017). the cd4+cxcr3+ cells were 18.86% ± 8.46% in healthy group, 30.78% ± 9.8% in pre-treated ms patients and 21.06% ± 9.23% in posttreated group (p

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عنوان ژورنال:
iranian journal of immunology

جلد ۸، شماره ۱، صفحات ۱-۱۰

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